Oxycodone Addiction Oxycodone works by stimulating certain opoid receptors that are located throughout the central nervous system, in the brain and along the spinal cord. When the oxycodone binds to the opoid receptors, a variety of physiologic responses can occur ranging from pain relief, to slowed breathing to euphoria. Withdrawal reactions include anxiety, irritability, sweating, trouble sleeping and diarrhea. Residential Treatment is a level of care that entails that the client live (resides) within a treatment facility for a specified duration of care; most often 28 days. Residential Treatment Programs and Centers usually include group and individual therapy sessions and span the confinement continuum from open campus to lock down facilities.